BOTULINUM TOXIN SINGAPORE

The Humble Guide to Botulinum Toxin in Aesthetic Medicine Singapore

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BOTULINUM TOXIN SINGAPORE PRICE

BOTOX SINGAPORE

We offer competitive prices that enables these treatments to be affordable for everyone.

Performed by MOH-certified doctor with 10+ years experience

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Basic

Dimpled Chin $36-$54

Crow's Feet $54-$90

Frown Lines $90-$180

Forehead Lines $90-$180

Jaw Slimming $270-$540

Advanced

Lip Flip $36-$54

Downturned Mouth $36-$54

Nefertiti Neck Lift $90-$180

Traptox $450-$900

TERMS & CONDITIONS
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BOTULINUM TOXIN SINGAPORE

Botulinum toxin type A, is recognized globally as a leading non-surgical cosmetic treatment, well-known for its efficacy in reducing the appearance of fine lines and wrinkles. In Singapore, where the pursuit of aesthetic perfection isn't just a luxury but a common desire among professionals of all ages, Botulinum Toxin treatments have become increasingly popular for temporary improvement of frown lines, crows feet lines and forehead lines.

Cosmetic

Reduction of facial wrinkles

Jaw muscles

Trapezius muscles

Medical

Treatment of muscle spasms

Chronic Migraines

Excessive sweating

1 Week to see results

Botulinum Toxin is incredibly versatile, capable of treating various aesthetic concerns that contribute to an aged appearance. It shouldn't be too long before you see improvements which generally occur within a week.

4 months of effects

Touch-ups and repeat visits are possible following a doctor's assessment of the effectiveness.You can expect effects potentially lasting up to 4 months. Wait at least 3 months before considering a top-up.

Treating Glabellar Lines

For treating glabellar frown lines (the vertical lines between the eyebrows, often called "11s"), botulinum toxin injections are typically administered into specific muscles. These muscles are responsible for the facial expressions that create these frown lines.

Injection Muscles for Glabellar Frown Lines:

Corrugator Supercilii
- Function: Draws the eyebrows inward and downward, creating vertical frown lines between the eyebrows.
Procerus
- Function: Pulls the skin of the nose upward, contributing to the formation of horizontal lines at the top of the nose and creating a "frowning" or "scrunching" appearance.
Depressor Supercilii
- Function: Lowers the medial part of the eyebrow, contributing to the frowning expression.

By weakening these muscles with injections, the lines between the eyebrows are smoothed, reducing the appearance of glabellar frown lines.

Price $90-180

Treating Forehead Lines

For treating forehead lines (horizontal lines that appear across the forehead), botulinum toxin injections are typically administered into specific muscles responsible for these expressions.

Injection Muscles for Forehead Lines:

Frontalis
- Function: Raises the eyebrows, causing horizontal lines to form across the forehead. By weakening the frontalis muscle with injections, these lines can be smoothed out.

In some cases, adjacent muscles may also be targeted to enhance results and prevent compensatory movements, but the primary muscle for forehead lines is the frontalis.

Price: $90-180

Treating Crow's Feet

For treating crow's feet lines (the fine lines that form at the outer corners of the eyes), botulinum toxin injections are typically administered into specific muscles responsible for these expressions.

Injection Muscles for Crow's Feet Lines:

Orbicularis Oculi
- Function: Responsible for closing the eyes and contributing to the squinting motion, which leads to the formation of crow's feet. By relaxing this muscle with injections, the appearance of these lines can be softened.

In some cases, additional areas around the eyes may be treated to enhance the overall effect and achieve a more youthful appearance.

Price: $54-90

Treating Dimpled Chin

For treating a dimpled chin (often referred to as "peau d'orange" appearance), botulinum toxin injections are typically administered into specific muscles responsible for this expression.

Injection Muscle for Dimpled Chin:

Mentalis
- Function: Elevates and protrudes the lower lip, causing a dimpled or textured appearance of the chin. By weakening the mentalis muscle with injections, the dimpled effect can be minimized, resulting in a smoother chin area.

By targeting the mentalis muscle, the appearance of a dimpled chin can be effectively reduced, leading to a more aesthetically pleasing chin profile.

Price: $36-54

Modified Nefertiti Neck Lift

For performing a Modified Nefertiti Neck Lift, botulinum toxin injections are typically administered into specific muscles responsible for the appearance of the neck and jawline.

Injection Muscle for Modified Nefertiti Neck Lift:

Platysma
- Function: Pulls the lower face and neck downward, contributing to neck bands and sagging jawline. By relaxing the platysma muscle with injections, the jawline can be better defined, and the neck area can appear smoother and more youthful.

By targeting the platysma muscle, the Modified Nefertiti Neck Lift can enhance jawline definition and improve the overall contour of the neck, achieving a more elegant profile. Stay lateral to avoid weakening the depressor labii inferioris muscle.

Price: $90-180

Treating Jaw Muscle

For treating masseter hypertrophy (enlargement of the masseter muscle, leading to a wider jawline), botulinum toxin injections are typically administered into specific muscles responsible for jaw function.

Injection Muscle for Masseter Hypertrophy:

Masseter
- Function: Closes the jaw and aids in chewing, contributing to a prominent, square-shaped jawline. By weakening the masseter muscle with injections, the muscle size is reduced, resulting in a slimmer jawline and a softer facial contour.

Targeting the masseter muscle effectively diminishes its hypertrophy, leading to a more aesthetically pleasing and defined jawline.

Price: $270-540

Treating Upper Lip (Lip Flip)

For enhancing the appearance of the upper lip without adding volume, botulinum toxin injections are typically administered into specific muscles that control lip movement.

Injection Muscle for Lip Flip:

Orbicularis Oris (Upper Portion)

Function: Encircles the mouth and controls lip movements such as puckering or pursing. By relaxing the upper portion of this muscle, the upper lip gently rolls outward, creating a fuller-looking lip and reducing the appearance of a gummy smile.

Targeting the orbicularis oris muscle allows for a natural-looking enhancement of the upper lip, offering a subtle lift and improved lip definition — often referred to as a "lip flip."

Price: $36-$54

Treating Downturned Mouth (DAO)

For correcting a downward pull at the corners of the mouth — often creating a sad or tired appearance — botulinum toxin injections are typically administered into the depressor anguli oris (DAO) muscle.

Injection Muscle for Lifting Mouth Corners:

Depressor Anguli Oris (DAO)

Function: Pulls the corners of the mouth downward. When overactive, this muscle contributes to a perpetual frowning or downturned mouth expression. By relaxing the DAO, the corners of the mouth lift subtly, creating a more neutral or pleasant resting expression.

Targeting the DAO muscle helps soften a sad or aged look, improving facial balance and rejuvenating the overall expression.

Price: $36-$54

Treating Trapezius Muscle (Traptox / Barbie Btx)

For treating trapezius hypertrophy (enlargement or overactivity of the trapezius muscle), botulinum toxin injections are typically administered into the upper fibers of the muscle. This treatment can provide both aesthetic slimming and therapeutic relief.

Injection Muscle for Trapezius Slimming:

Trapezius (Upper Fibers)

Function: Elevates the shoulders and supports neck movement. When overactive or bulky, the trapezius can contribute to a broad, tense shoulder appearance and neck discomfort. By weakening this muscle with injections, the shoulder line becomes slimmer and tension is reduced.

Targeting the trapezius muscle results in a more elongated neckline, a softer shoulder contour, and relief from tightness — an effect popularly known as “Barbie Btx.”

Price: $450-$900

1. What Is Botulinum Toxin Singapore?

Scientifically known as Botulinum toxin, it is a neurotoxin produced by the bacterium *Clostridium botulinum*. It's used in medicine to treat various muscle-related conditions and cosmetically to eliminate wrinkles by temporarily paralyzing facial muscles.

Botulinum toxin, commonly known for its use in cosmetic procedures, is a highly effective injectable treatment used to reduce the appearance of fine lines and wrinkles. Popular in Singapore for non-surgical facial rejuvenation, botulinum toxin works by temporarily relaxing the muscles responsible for dynamic wrinkles, such as frown lines, crow’s feet, and forehead lines. This minimally invasive treatment offers a quick and efficient way to achieve a youthful, refreshed appearance without the need for surgery.

Whether you’re looking to smooth forehead wrinkles, soften crow’s feet, or diminish frown lines, botulinum toxin provides fast results with little to no downtime. It’s also used in medical treatments for conditions like excessive sweating, chronic migraines, and muscle spasms.

As a leading non-surgical aesthetic solution, botulinum toxin injections are a top choice for individuals in Singapore seeking a safe, effective, and minimally invasive approach to skin rejuvenation. To ensure optimal results and safety, always seek treatment from qualified and experienced professionals in reputable clinics.

2. How Botulinum Toxin Singapore is administered at Nee Soon Clinic

At Nee Soon Clinic, we use an "Invisible Needle" that is 33% thinner than a 30G needle (which is an insulin needle). This extremely small needle results in a near painless experience for patients with the following benefits:

Minimal bruising
Near painless experience
Less bleeding

3. How does Botulinum Toxin work?

Botulinum Toxin is used to reduce the appearance of facial lines by temporarily blocking nerve impulses directed towards the muscles where it is injected. It functions by blocking the release of acetylcholine, a chemical messenger that signals muscles to contract. When it is injected into specific facial muscles, it prevents these muscles from contracting, resulting in the relaxation and softening of wrinkles.

Step 1 Consultation

A session usually starts with a detailed discussion about your aesthetic goals and medical history.

Step 2 Injection

Small doses are injected into targeted areas. Improvements are generally seen within 1 week after treatment and the treatment effect can last for up to 4 months.

Step 3 Follow-Up

Assessment of the treatment's effectiveness and any touch-ups if necessary.

4. Aesthetic concerns addressed by Botulinum Toxin Singapore

Below is a list of common concerns addressed by Botulinum Toxin, paired with the approximate units typically used:

5. Is Botulinum Toxin Singapore Right for You?

Ideal candidates for Botulinum Toxin are those seeking to reduce the appearance of facial wrinkles and lines without undergoing surgical procedures. It is suitable for most adults who are in good health and have realistic expectations about the outcomes of the treatment.

Here's a quick checklist to see if this is right for you

Age: Typically 30 years or older

Skin condition: Presence of dynamic wrinkles

Health status: No neuromuscular diseases

Expectations: Looking for non-permanent solutions

6. What to Prepare and Expect During Botulinum Toxin Singapore

Preparation for Botulinum Toxin:

Avoid certain medications

Aspirin and anti-inflammatory drugs should be avoided to reduce bruising.

No alcohol

Avoid alcohol a few days before the procedure to minimize swelling.

During the Procedure:

Duration

Each session typically lasts about 10-15 minutes.

Sensation

Minimal discomfort, akin to a quick pinch.

Pointers for a Smooth Injection Experience:

Choose a reputable clinic: Ensure the clinic is well-established and has certified practitioners.

Clear communication: Discuss all your concerns and aesthetic goals with the practitioner beforehand.

7. Post-Treatment Care and Recovery

After injections, you can expect to resume normal activities immediately. However, to ensure the best results and minimize side effects, follow these tips:

Post-Treatment Care Tips:

Do not rub the treated areas for 24 hours after the procedure: This could cause the Botulinum Toxin to spread to unwanted areas. You can cleanse your face but try not to rub it.
Stay upright: Avoid lying down for 4 hours after the injections and avoid excessive bending down or strenuous exercise on the day of treatment.
Avoid applying make-up before, during and immediately after treatment.

8. Botulinum Toxin Singapore Treatment Protocol for Optimal Results

For the best results, it’s crucial to adhere to a treatment protocol that involves regular follow-ups and maintenance sessions. Typically, the effects of Botulinum Toxin last about 3-6 months, and scheduling follow-up treatments can help maintain the youthful appearance it provides.

9. Combining with Other Aesthetic Treatments

Botulinum Toxin can be effectively combined with other cosmetic procedures such as fillers, chemical peels, or laser treatments for a more comprehensive aesthetic overhaul. This multi-treatment approach addresses skin texture, volume, and wrinkles more holistically.

For more information or to book a consultation, contact us.

10. The Science Behind

Mechanism of Action

1. Botulinum Toxin Production:

Botulinum toxin is produced by the bacterium Clostridium botulinum. This toxin is categorized as one of the most lethal substances known; however, when used in minute doses, it serves therapeutic purposes. The toxin consists of a heavy chain (about 100 kDa) and a light chain (about 50 kDa) that remain linked by a disulfide bond.

2. Binding to Nerve Endings:

The action of Botulinum Toxin begins with its binding to presynaptic motor nerve endings at the neuromuscular junction. The heavy chain of the botulinum toxin binds to specific receptors on the surface of the nerve terminals, primarily the nicotinic acetylcholine receptors and gangliosides, facilitating the uptake of the toxin into the nerve cells.

3. Internalization and Translocation:

Following binding, the toxin is internalized into the nerve ending through receptor-mediated endocytosis. Once inside the nerve cell, the acidic environment of the endosome triggers a conformational change in the toxin, allowing the light chain to translocate into the cytosol of the neuron.

4. Proteolytic Activity:

The light chain of botulinum toxin possesses zinc-dependent endopeptidase activity, allowing it to cleave essential proteins involved in the release of acetylcholine, a neurotransmitter responsible for muscle contraction. The primary targets of the light chain are soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins, specifically SNAP-25, synaptobrevin, and syntaxin. These proteins are crucial for the fusion of synaptic vesicles containing acetylcholine with the presynaptic membrane.

11. Safety and Regulation

In Singapore, the use of botulinum toxin is strictly regulated by the Health Sciences Authority (HSA). Only approved medical professionals can administer these treatments, and only HSA-approved brands can be used in clinics.

Our clinic adheres strictly to all MOH and HSA guidelines. Treatments are only offered after a proper medical consultation with a licensed doctor.

12. The History of Botulinum Toxin

Botulinum toxin is now widely recognised as a safe and effective tool in aesthetic medicine, neurology, and beyond — but its story begins in a much more unexpected, and even dangerous, place. What started as a feared foodborne toxin has evolved into one of the most extensively studied therapeutic agents in modern medicine.

From Food Poisoning to Scientific Discovery
The tale begins in the late 18th century, when German physician Justinus Kerner investigated mysterious cases of food poisoning linked to spoiled sausages. He documented symptoms such as muscle paralysis and respiratory failure, and coined the term “sausage poison”. Remarkably, Kerner hypothesised that this substance could have medical potential — suggesting it might be used to treat overactive nerves or muscle conditions. Though he couldn’t prove it at the time, he laid the foundation for future breakthroughs.

In 1895, Belgian bacteriologist Emile Van Ermengem successfully isolated the bacterium behind this deadly condition — naming it Clostridium botulinum. This discovery marked a turning point in microbiology and toxicology, enabling scientists to better understand and eventually harness the properties of the botulinum toxin.

Understanding the Mechanism: A Powerful Neurotoxin
Botulinum toxin works by blocking the release of acetylcholine, a key neurotransmitter that allows muscles to contract. When injected into targeted areas in extremely small, purified doses, it temporarily relaxes the muscles — a feature that would later prove useful in both medical and cosmetic contexts.

While the botulinum toxin is considered one of the most potent naturally occurring substances, its safety profile in controlled doses is well-established. In fact, this precision makes it suitable for treating both functional disorders and cosmetic concerns related to muscle activity.

First Medical Applications
In the 1970s, researchers began exploring therapeutic uses for botulinum toxin in human medicine. A turning point came when American ophthalmologist Dr. Alan Scott started using it to treat strabismus, a condition in which the eyes are misaligned due to overactive eye muscles. It was also effective in treating blepharospasm, a condition involving involuntary blinking.

Following extensive clinical trials, botulinum toxin type A — branded as Botox® — received its first FDA approval in 1989 for the treatment of eye muscle disorders and facial spasms. This marked the first official recognition of botulinum toxin as a safe, effective injectable therapy in modern medicine.

The Accidental Aesthetic Breakthrough
While initially developed for medical use, the cosmetic benefits of botulinum toxin were discovered serendipitously. In the early 1990s, Canadian ophthalmologist Dr. Jean Carruthers and her dermatologist husband, Dr. Alastair Carruthers, observed that patients treated for eye conditions experienced a softening of facial wrinkles — especially in the frown area between the brows.

This observation launched a new era. In 2002, the U.S. FDA approved Botox® Cosmetic specifically for aesthetic use — namely, the temporary improvement of glabellar lines (the vertical lines between the eyebrows). This approval ignited a global surge in non-surgical aesthetic procedures.

Since its cosmetic debut, the use of botulinum toxin has expanded exponentially. Beyond Botox®, other botulinum toxin brands such as Dysport® and Xeomin® have emerged, each offering unique formulation characteristics.

Disclaimer:
The information provided in this article is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The content is not intended to be a comprehensive source of information and should not be relied upon as such. Reliance on any information provided in this article is solely at your own risk. The authors and the publisher do not endorse or recommend any specific tests, physicians, products, procedures, opinions, or other information that may be mentioned in the article. Any reliance on the information in this article is solely at the reader's own risk.

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